Through evolution, enzymes have developed subtle modes of activation in order to ensure the sufficiently high substrate specificity required by modern cellular metabolism.One of these modes is the use of a target-dependent module (i.e.a docking domain) such as those found in signalling kinases.Upon the binding of the target to a docking domain, the
I am pleased to have the opportunity to react to Bruce Ingraham's response to my article ‘Networks and learning: communities, practices and the metaphor of networks' (Jones, 2004).It is rare to have a dialogue with someone who has taken the time and trouble to consider what you have written GINKOGIN for a journal.All too often
The aim of the article is to depict the issue of commemorating Plug foreign partnerships of municipalities present in the public space.The municipalities of the Gniezno district were selected as a case study.The author initially verified the following hypothesis: although foreign cooperation is an optional and secondary task of municipalities, thei
Abstract Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes.Therefore, MMPs constitute important targets for drug design, development and delivery.Advanced proteomic technologies have identified type-specific target substrates; however, the complete repertoire of MMP sub
The article provides a clear definition of general cultural competence of the future specialist, it is shown that they alphapro represent a social expectation of the fact that a graduate student entering into the social life, shares the values that prevail in this society: high moral characteristics and values of humanism, has a common language, le